Epigenetic Regulation During Pregnancy
Cross-correlating epigenetics with the findings on pregnancy-induced brain restructuring provides an opportunity to explore how genetic expression and environmental influences interact dynamically during the developmental stage known as matrescence . Here are key intersections between the two: 1. Epigenetic Regulation During Pregnancy Maternal Brain Changes : The widespread anatomical changes reported by Pritschet et al. are likely regulated by epigenetic mechanisms such as DNA methylation, histone modification, and changes in non-coding RNA. These mechanisms can be triggered by pregnancy-specific hormonal shifts, including levels of estrogen, progesterone, and oxytocin. Gene Expression : Genes involved in synaptic plasticity, neurogenesis, and neuronal pruning may be upregulated or silenced in specific brain regions (e.g., the prefrontal cortex, hippocampus, and amygdala) to prepare for caregiving behaviors. 2. Environmental and Hormonal Triggers Cortisol and Stress Regulation : Pregn...